专利内容由知识产权出版社提供
专利名称：Compositions for neutralization of
lipopolysaccharides
发明人：Samuel D. Wright,Mark M. Wurfel,Peter Eric
Hailman
申请号：US08/337611申请日：19941110公开号：US05932536A公开日：19990803
摘要：The present invention relates to compositions and methods for neutralizinglipopolysaccharide, and treatment of gram-negative sepsis based therein. Accordingly,the invention is directed to a composition of homogeneous particles comprising
phospholipids and a lipid exchange protein, such as phospholipid transfer protein or LPSbinding protein. The lipid exchange protein is characterized by being capable offacilitating an exchange protein of lipopolysaccharide into the particles. In a specificembodiment, exemplified herein, the lipid particles are high density lipoprotein particlescomprising apolipoprotein A-I (apo A-I) , a phospholipid, and cholesterol or a lipid bilayerbinding derivative thereof. In a specific example, the phospholipid is phosphatidylcholine(PC). In a specific example, the ratio of phosphatidylcholine:cholesterol:apolipoprotein A-Iis approximately 80:4:1. The levels of LPS exchange protein activity in a sample from apatient provides a diagnostic, monitoring, or prognostic indicator for a subject withendotoxemia, gram-negative sepsis, or septic shock.
申请人：THE ROCKEFELLER UNIVERSITY
代理机构：Klauber & Jackson
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