专利内容由知识产权出版社提供
专利名称：Antibodies for depletion of ICOS-positive
cells in vivo
发明人：Richard Kroczek申请号：US11578215申请日：20050422公开号：US083105B2公开日：20121127
摘要：The present invention relates generally to binding agents useful in the selectivedepletion of T cells in vivo. More specifically, the invention relates to ICOS-binding agentswhich once bound to ICOS expressed on the surface of cells, in particular ICOS-bearingactivated T cells, result in the in vivo depletion of cells to which they are bound. Methodsof treating T cell related diseases using said ICOS-binding agents, and pharmaceuticalcompositions comprising said ICOS-binding agents, a method of identifying an ICOS-binding agent, and monoclonal anti-ICOS antibodies capable of eliminating cells in vivowhich express ICOS on their surface are also provided.
申请人：Richard Kroczek
地址：Berlin DE
国籍：DE
代理机构：Clark & Elbing LLP
更多信息请下载全文后查看
